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Diagnostic pitfalls associated with fine‐needle aspiration biopsy in a patient with the myxoid variant of monophasic fibrous synovial sarcoma
Author(s) -
Bergman Simon,
Brownlee Noel A.,
Geisinger Kim R.,
Ward William G.,
Pettenati Mark J.,
Koty Patrick,
Ellis Ezra,
Beaty Michael W.,
Kilpatrick Scott E.
Publication year - 2006
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.20566
Subject(s) - medicine , synovial sarcoma , biopsy , sarcoma , fine needle aspiration , pathology , radiology
Abstract Synovial sarcoma (SS) is one of the most common soft tissue tumors that typically presents in the extremities of young adults, but may occur at any site and affect children during the first decade. Herein we discuss a 12‐yr‐old male who complained of left foot pain and plantar mass. A fine‐needle aspiration biopsy of an 8 cm subcutaneous mass was performed revealing a myxoid spindle cell neoplasm. The cytologic differential diagnosis included a myxoid neurofibroma, neurothekeoma, and a myxoid sarcoma. Subsequent excision of the mass revealed a monophasic fibrous SS with myxoid features. Examination of the tissue by fluorescence in situ hybridization confirmed the presence of characteristic SS SYT gene rearrangement at chromosome 18q11.2. This case underscores that the cytologic distinction of mxyoid spindle cell tumors may be challenging. We report the cytologic features of a myxoid monophasic fibrous SS, and discuss its distinction from other benign and malignant myxoid soft tissue neoplasms. Diagn. Cytopathol. 2006;34: 761–767. © 2006 Wiley‐Liss, Inc.