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Improvement of diagnostic accuracy and screening conditions with liquid‐based cytology
Author(s) -
Schledermann Doris,
Ejersbo Dorthe,
Hoelund Berit
Publication year - 2006
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.20515
Subject(s) - medicine , dysplasia , liquid based cytology , cytology , papanicolaou stain , carcinoma in situ , diagnostic accuracy , population , carcinoma , bethesda system , squamous intraepithelial lesion , pathology , radiology , cervical intraepithelial neoplasia , cancer , cervical cancer , environmental health
The aim of this population‐based study was to compare the histological follow‐up diagnoses of cervicocytological neoplasia (dysplasia, carcinoma in situ and carcinoma) in conventional Papanicolaou (CP) smear and ThinPrep® PapTest™ samples (TP). All cytological samples from the County of Funen, Denmark, in the periods 2000 (n = 34,832) and 2002 (n = 29,995) were included in the study. In 2000 and 2002, the specimens were CP and TP, respectively. The detection rate of ≥ mild dysplasia was 0.8% in CP and 1.4% in TP, showing a 75% increase in TP when compared with CP (p < 0.001). Histological follow‐up of ≥ moderate dysplasia revealed a neoplastic lesion in 77.1% and 87.9% in CP and TP, respectively (P < 0.001). The present study indicates that the diagnostic accuracy of cervical cytology is improved with liquid‐based cytology. In addition, we focus on the optimized cellular material that shows the diagnostic details very clearly to the microscopist and leads to radically improved screening conditions. Diagn. Cytopathol. 2006;34: 780–785. © 2006 Wiley‐Liss, Inc.