Lobular carcinoma with cytoplasmic granules | Zendy

Vdovenko Alexandre | Zendy; Bass Randall | Zendy; TauchiNishi Pamela | Zendy; Namiki Thomas | Zendy

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Lobular carcinoma with cytoplasmic granules

Author(s) -

Vdovenko Alexandre,

Bass Randall,

TauchiNishi Pamela,

Namiki Thomas

Publication year - 2001

Publication title -

diagnostic cytopathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.417

H-Index - 65

eISSN - 1097-0339

pISSN - 8755-1039

DOI - 10.1002/dc.2049

Subject(s) - medicine , pathology , lobular carcinoma , breast carcinoma , differential diagnosis , carcinoma , metastatic carcinoma , sarcoma , invasive lobular carcinoma , cytopathology , lymphoma , cytology , breast cancer , ductal carcinoma , cancer , invasive ductal carcinoma

We report on a case of invasive lobular carcinoma of the breast with a previously undescribed cytologic feature. Diff‐Quik‐stained cytologic preparations showed uniform single cells with prominent coarse cytoplasmic granules. Ultrastructurally, the granules showed features suggestive of autophagosomes and/or degenerative mitochondria. The cytologic differential diagnosis included granulocytic sarcoma, metastatic melanoma, extramedullary hematopoiesis, large granulocytic leukemia/lymphoma, and mast‐cell tumor. Adjunctive studies were helpful in the diagnosis of carcinoma. Histologic study of the mastectomy specimen showed classic type of invasive lobular carcinoma. Diagn. Cytopathol. 25:253–257, 2001. © 2001 Wiley‐Liss, Inc.

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