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Lobular carcinoma with cytoplasmic granules
Author(s) -
Vdovenko Alexandre,
Bass Randall,
TauchiNishi Pamela,
Namiki Thomas
Publication year - 2001
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.2049
Subject(s) - medicine , pathology , lobular carcinoma , breast carcinoma , differential diagnosis , carcinoma , metastatic carcinoma , sarcoma , invasive lobular carcinoma , cytopathology , lymphoma , cytology , breast cancer , ductal carcinoma , cancer , invasive ductal carcinoma
We report on a case of invasive lobular carcinoma of the breast with a previously undescribed cytologic feature. Diff‐Quik‐stained cytologic preparations showed uniform single cells with prominent coarse cytoplasmic granules. Ultrastructurally, the granules showed features suggestive of autophagosomes and/or degenerative mitochondria. The cytologic differential diagnosis included granulocytic sarcoma, metastatic melanoma, extramedullary hematopoiesis, large granulocytic leukemia/lymphoma, and mast‐cell tumor. Adjunctive studies were helpful in the diagnosis of carcinoma. Histologic study of the mastectomy specimen showed classic type of invasive lobular carcinoma. Diagn. Cytopathol. 25:253–257, 2001. © 2001 Wiley‐Liss, Inc.