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Polyoma virus infection is a prominent risk factor for bladder carcinoma in immunocompetent individuals
Author(s) -
Weinreb David B.,
Desman Garrett T.,
AmolatApiado May Jennifer M.,
Burstein David E.,
Godbold James H.,
Johnson Edward M.
Publication year - 2006
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.20429
Subject(s) - medicine , genitourinary system , incidence (geometry) , carcinoma , prostate , risk factor , odds ratio , pathology , oncology , immunology , cancer , physics , optics
Despite various reports of BK viral (BKV) DNA sequences or proteins in tumors of the urogenital tract, there has been no study statistically linking infection by this polyoma virus (PV) to tumor development. All PV are potential transforming viruses, the large T‐antigen of which interacts with tumor suppressor proteins. Here, we have performed a cross‐sectional study of 3,782 patients having had urine cytologic analyses, comparing those diagnosed with PV infection with those not so diagnosed. In order to focus on immunocompetent individuals, renal transplant patients, for whom a diagnosis of PV infection followed immunosuppressive therapy, were excluded. Among the 133 immunocompetent patients diagnosed with PV infection, the most frequently occurring neoplasms were bladder carcinoma (15.8%) and prostate carcinoma (3.8%). The incidence of bladder carcinoma was sufficient to statistically establish temporality in a two‐sided test, linking a prior diagnosis of PV infection to a subsequent diagnosis of bladder carcinoma (odds ratio = 3.419, P < 0.001). Diagn. Cytopathol. 2006;34:201–203. © 2006 Wiley‐Liss, Inc.