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Transthoracic needle biopsy in the diagnosis of large‐cell neuroendocrine carcinoma of the lung
Author(s) -
Marmor Sylvia,
Koren Rumelia,
Halpern Marisa,
Herbert Mehrdad,
RathWolfson Lea
Publication year - 2005
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.20359
Subject(s) - medicine , pathology , lung , cytology , carcinoma , biopsy , immunohistochemistry , fine needle aspiration cytology , small cell lung carcinoma , fine needle aspiration , small cell carcinoma , radiology
To determine the effect of cytological diagnosis, fine‐needle aspiration and brush cytology on lung tumors and core‐needle biopsy, we retrospectively reviewed 11 cases of large‐cell neuroendocrine carcinoma (LCNEC) found in our archives between the years 1997 and 2004. The preoperative cytological diagnosis of LCNEC is challenging because of the broad histologic similarity to other neuroendocrine tumors of the lung. The original cytologic diagnosis was LCNEC in nine of the cases while the remaining two were misdiagnosed as small‐cell lung carcinoma. Smears were composed of clusters of intermediate‐size cells with amphophylic cytoplasm, some with large nuclei and prominent nucleoli. In two of the cases there was discordance between the cytological findings and the immunohistochemical results. The cytological findings were correlated with histopathological observations. Diagn. Cytopathol. 2005;33:238–243. © 2005 Wiley‐Liss, Inc.