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Fine‐needle aspiration cytology of pancreatoblastoma in a young woman: Report of a case and review of the literature
Author(s) -
Zhu LeeChing,
Sidhu Gurdip S.,
Cassai Nicholas D.,
Yang Grace C.H.
Publication year - 2005
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.20355
Subject(s) - chromogranin a , pathology , fine needle aspiration , synaptophysin , cytology , medicine , biopsy , stromal cell , stromal tumor , immunohistochemistry
Abstract Pancreatoblastoma is a rare tumor and has been reported only four times in the cytologic literature, three times in fine‐needle aspiration (FNA) biopsy and once in an imprint of resected tumor. We are reporting the fourth case of FNA cytology with immunohistochemical and electron microscopic studies. The patient is a 24‐yr‐old African American woman, who presented with a pancreatic mass, hepatic masses, and abdominal lymphadenopathy. The aspiration smears of the liver mass showed a biphasic tumor composed of bland‐appearing primitive spindled stromal fragments with “spider‐web”‐like long fibrils interconnecting with sharply angulated islands of cohesive epithelium. At high power, the epithelium is composed of medium‐sized cells with round‐to‐oval vesicular nuclei with fine chromatin and one‐to‐two small nucleoli. The neuroendocrine component was demonstrated immunohistochemically with synaptophysin and chromogranin expressions. The acinar component and squamoid component were demonstrated ultrastructurally by the presence of 400–600 nm zymogen granules and tonofilaments. The literature was reviewed and the cytological features of all the four cases of pancreatoblastoma are summarized. Diagn. Cytopathol. 2005;33:258–262. © 2005 Wiley‐Liss, Inc.