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Paired ductal lavage and fine‐needle aspiration specimens from patients with breast carcinoma
Author(s) -
Brogi Edi,
Miller Mara Jo,
Casadio Chiara,
Ljung BrittMarie,
Montgomery, Leslie
Publication year - 2005
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.20354
Subject(s) - atypia , medicine , fine needle aspiration , pathology , carcinoma , cytopathology , cytology , sampling (signal processing) , ductal carcinoma , breast carcinoma , biopsy , breast cancer , cancer , filter (signal processing) , computer science , computer vision
Ductal lavage (DL) is a new procedure for sampling of the mammary epithelium, but experience with this technique remains limited. We compared the findings in paired DL and fine‐needle aspiration (FNA) specimens obtained from patients with breast carcinoma. Four reviewers evaluated all DL samples. Two reviewers also examined the FNA material and compared cellular composition and morphologic findings in paired samples. DL and FNA samples from six patients were satisfactory for evaluation. Two DL samples showed marked atypia, one showed mild atypia, and two were benign; there was no agreement in one case (mild atypia vs. benign). Overall, the atypical cells in DL samples resembled those in the paired FNA material, but low degree of cytologic atypia and relative paucity of atypical cells limited their correct identification. The interpretation of DL samples is more challenging than that of FNA material, but similar criteria apply. To increase the sensitivity of DL, the number of epithelial cells required for a satisfactory sample should be higher than previously set. Diagn. Cytopathol. 2005;33:370–375. © 2005 Wiley‐Liss, Inc.