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Fine‐needle aspiration cytology of angiomatoid malignant fibrous histiocytoma
Author(s) -
Lemos Maria Manuel,
Karlen Jonas,
Tani Edneia
Publication year - 2005
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.20312
Subject(s) - medicine , cytology , cytopathology , pathology , fine needle aspiration , fine needle aspiration cytology , radiology , biopsy
Angiomatoid malignant fibrous histiocytoma (AMFH) is a rare, low‐grade malignant mesenchymal neoplasm that affects mostly the extremities of children and young adults. Excisional surgery is the adequate treatment. The cytologic, immunocytologic, and histologic features noted in two patients having AMFH are presented. Cytologic smears showed histiocyte‐like cells dispersed and in clusters, in close relation with eosinophilic mesenchymal fragments in a bloody background with lymphocytes. The tumor cells showed mild to moderate anisocariosis, often with nucleolus and vast, fragile cytoplasm. A fibroblastic‐like spindle to ovoid cell population was also present in one patient. Immunohistochemical results are most consistent with myofibroblastic cell differentiation. When accompanied by adequate clinical information and ancillary techniques, a specific preoperative cytologic diagnosis is possible. Diagn. Cytopathol. 2005;33:116–121. © 2005 Wiley‐Liss, Inc.