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Fine‐needle aspiration cytology of pancreatic somatostatinoma: The importance of immunohistochemistry for the cytologic diagnosis of pancreatic endocrine neoplasms
Author(s) -
Stelow Edward B.,
Woon Carolyn,
Pambuccian Stefan E.,
Thrall Michael,
Stanley Michael W.,
Lai Rebecca,
Mallery Shawn,
Gulbahce H. Evin
Publication year - 2005
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.20305
Subject(s) - medicine , cytology , endocrine system , immunohistochemistry , pathology , pancreas , enteroendocrine cell , fine needle aspiration , fine needle aspiration cytology , biopsy , hormone
Pancreatic somatostatinoma is a rare pancreatic endocrine neoplasm representing as little as 1% of pancreatic endocrine neoplasms (PENs). The histologic features of this tumor are like those of other PENs, except that it commonly forms acinar structures and often has cells with abundant, granular cytoplasm. We have recently encountered two of these neoplasms sampled by endoscopic ultrasound (EUS)‐guided fine‐needle aspiration (FNA). We discuss the cytologic and immunohistochemical findings of these two cases and the cytologic similarities these neoplasms share with pancreatic acinar‐cell carcinoma (PACC). We review the cytologic features of PEN and PACC and discuss the importance of cell block immunohistochemistry in the diagnosis of pancreatic neoplasia sampled by EUS‐guided FNA. Diagn. Cytopathol. 2005;33:100–105. © 2005 Wiley‐Liss, Inc.