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Small‐cell tumors of the liver: A cytological study of 91 cases and a review of the literature
Author(s) -
Khalbuss W.E.,
Grigorian S.,
Bui M.M.,
Elhosseiny A.
Publication year - 2005
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.20255
Subject(s) - medicine , pathology , general surgery
Abstract This study was designed to consider the cytomorphological spectrum, differential diagnosis, and the role of ancillary studies in small‐cell tumors of the liver. Three independent pathologists reviewed cytological slides from 91 cases of small‐cell tumors of the liver. The results were compared with the findings of three recently published studies (Cytopathology 11 (2000) 262–267; Diagn Cytopathol 19 (1998) 29–32; and Acta Cytol 40 (1996) 937–947). The role of immunohistochemistry in reaching timely and specific diagnoses was also examined. The diagnostic categories included 44 cases of metastatic small‐cell undifferentiated carcinoma, 15 cases of metastatic neuroendocrine carcinoma, 10 cases of metastatic adenocarcinoma, 7 cases of malignant lymphoma, 4 cases of hepatocellular carcinoma with small‐cell features, 2 cases of cholangiocarcinoma, 1 case of poorly differentiated carcinoma, and 8 cases of rare tumors including granulosa cell tumor (2 cases), sarcoma (4 cases), malignant melanoma with small‐cell features (1 case), and meningioma with small‐cell features (1 case). Metastatic granulosa cell‐tumor, metastatic melanoma, and metastatic meningioma should be included in the differential diagnoses of small‐cell malignancies found in the liver. Diagn. Cytopathol. 2005;33:8–14. © 2005 Wiley‐Liss, Inc.