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Chromatin pattern alteration in malignant cells: An enigma
Author(s) -
Dey Pranab
Publication year - 2005
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.20187
Subject(s) - chromatin , scaffold/matrix attachment region , microbiology and biotechnology , histone , histone h2b , biology , chromatin remodeling , cell nucleus , nucleus , dna , genetics
Alteration of chromatin pattern is one of the most important clues to detect the malignant cell. However, the exact cause of change of chromatin pattern still is not clearly known. Recently, in last 20 yr, modern advanced technologies, such as fluorescent in situ hybridization (FISH), chromosome painting, green fluorescent protein (GFP) fusion technology, fluorescent recovery after photobleaching (FRAP), confocal microscopy, and multicolor four‐dimensional imaging of living cell, have unfolded the mystery of the chromatin structure and dynamics. In this study, I have discussed the possible causes of chromatin change in malignant cells based on available recent information. Multiple factors are responsible for alteration of chromatin pattern in malignant cells. The important factors in this respect are chromatin relocation, DNA aneuploidy, change of nuclear matrix protein (NMP), histone protein alteration, abnormal nuclear lamin‐chromatin interaction, and nuclear pore dysfunction. It is not impossible that the chromatin pattern alteration may be just a secondary change due to the interaction of fixative with chromatin and nonchromatinic substances in the nucleus. Diagn. Cytopathol. 2005;32:25–30. © 2005 Wiley‐Liss, Inc.