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Histiocytes containing immunoglobulin crystals in the urine of a patient with IgA κ plasmacytoma of the bladder
Author(s) -
Miller Dylan V.,
McClure Rebecca F.,
Crawford Barbara G.,
Zeldenrust Steven R.,
Leibovich Bradley C.,
Sebo Thomas J.
Publication year - 2004
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.20083
Subject(s) - histiocyte , pathology , plasma cell , medicine , antibody , plasmacytoma , urine , cytoplasm , urine cytology , cystoscopy , plasma cell dyscrasia , bence jones protein , biology , multiple myeloma , immunology , bone marrow , immunoglobulin light chain , biochemistry , alternative medicine
Exfoliative cytology specimens from patients with plasma cell dyscrasias are rarely diagnostic, though there are reports of neoplastic plasma cells observed in pleural fluid and urine. Immunoglobulin concretions or crystals associated with neoplastic plasma cell populations have been well described. These crystals may be found within plasma cell nuclei or cytoplasm, extracellularly, or within cells of histiocytic lineage where they are presumably derived by phagocytosis. To the best of our knowledge, this is the first report of immunoglobulin crystals within histiocytes in the urine of a patient with plasmacytoma. A 61‐year‐old male underwent routine cystoscopy and urine collection to evaluate hematuria. The bladder biopsy demonstrated IgA κ‐producing plasmacytoma. Urine cytopsin preparations did not contain plasma cells, but there were histiocytic cells with degenerative nuclei and eccentrically located cytoplasmic spherical refractile hyaline crystals thought to be immunoglobulin crystals. This was supported by immunocytochemical staining. Diagn. Cytopathol. 2004;31:48–51. © 2004 Wiley‐Liss, Inc.