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Atypical teratoid/rhabdoid tumor: Cytology and differential diagnosis in adults
Author(s) -
Raisanen Jack,
Hatanpaa Kimmo J.,
Mickey Bruce E.,
White Charles L.
Publication year - 2004
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.20064
Subject(s) - atypical teratoid rhabdoid tumor , differential diagnosis , medicine , pathology , immunohistochemistry , cytology , smarcb1 , posterior fossa , anatomy , gene , biology , biochemistry , chromatin remodeling , chromatin
Atypical teratoid/rhabdoid tumors (AT/RTs) are malignant intracranial neoplasms that usually occur in the posterior fossa of children. They are characterized by cells with paranuclear rhabdoid inclusions, a mesenchymal and epithelial immunohistochemical profile, and 22q deletions with inactivation of the INI1/hSNF5 gene. Although they usually occur in young children, AT/RTs are being recognized in adults with increasing frequency. We report the cytologic features of an AT/RT from the cerebellum of a 45‐year‐old man and discuss the differential diagnosis in adults. Diagn. Cytopathol. 2004;31:60–63. © 2004 Wiley‐Liss, Inc.
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