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Fine‐needle aspiration cytology of bilateral renal malakoplakia
Author(s) -
Gupta Mamta,
Venkatesh Sudhakar K.,
Kumar Anant,
Pandey Rakesh
Publication year - 2004
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.20050
Subject(s) - malakoplakia , medicine , malacoplakia , cytology , pathology , cytopathology , fine needle aspiration , biopsy
Isolated bilateral renal malakoplakia in the absence of concomitant involvement of the urinary tract is a rare occurrence. We report imaging, cytologic, and histologic findings of such a case diagnosed initially by fine‐needle aspiration (FNA) cytology. A 26‐yr‐old female presented with pain in the left flank, fever, anorexia, and weight loss for the past 2 mo. A left lumbar lump was palpable on physical examination. Imaging studies showed an enlarged nonfunctioning left kidney and a small lesion in the right kidney with preserved function. FNA from both kidneys yielded purulent material positive for E. coli on culture. The smears were inflammatory, with a predominance of neutrophilic polymorphs and numerous histiocytes along with some intracellular and extracellular Michaelis‐Guttman bodies, which were highlighted with the use of a PAS stain. Histology of the nephrectomy specimen showed ill‐defined nodules, composed of foamy histiocytes intermingled with neutrophils, plasma cells, and many variably sized concentric laminated bodies. The right‐side lesion resolved with the use of broad‐spectrum antibiotics in conjunction with ascorbic acid and bethanecol. When imaging studies are suggestive of a chronic inflammatory process, renal malakoplakia must always be considered in the differential diagnosis even if aspirated material shows a predominance of polymorphonuclear leukocytes. The use of special stains like PAS, Von Kossa, and Perl's helps in reaching the correct diagnosis. Diagn. Cytopathol. 2004;31:116–117. © 2004 Wiley‐Liss, Inc.