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Microglandular hyperplasia has a cytomorphological spectrum overlapping with atypical squamous cells—cannot exclude high‐grade squamous intraepithelial lesion (ASC‐H)
Author(s) -
Shidham Vinod B.,
Rao R. Nagarjun,
Machhi Jinobya,
Chavan Ashwini
Publication year - 2004
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.10342
Subject(s) - pathology , medicine , squamous intraepithelial lesion , lesion , biopsy , cervical intraepithelial neoplasia , cancer , cervical cancer
We retrospectively evaluated cytological interpretations of conventional cervical smears in 48 cases of biopsy‐proven microglandular hyperplasia and compared them with 15 negative controls. A glandular pattern was noted in all 48 cases but was predominant in 73% (35/48) of the cases. Immature metaplastic pattern was present in 71% (34/48) and was predominant in 27% (13/48). These features were not observed in negative control smears. 85% of cases (41/48) were interpreted as negative for epithelial cell abnormality. Two cases with predominantly glandular pattern (6%, 2/35) were interpreted as atypical glandular cells. Five cases with predominantly immature metaplastic pattern (38%, 5/13) showed checkerboard arrangement or rows of single cells with slightly larger atypical nuclei leading to interpretation as “atypical squamous cells—cannot exclude high‐grade squamous intraepithelial lesion.” The metaplastic cells with normoblast‐like karyorrhectic apoptotic debris confined to the nuclear area were scattered among these cells in microglandular hyperplasia with metaplastic pattern. Diagn. Cytopathol. 2004;30:57–61. © 2004 Wiley‐Liss, Inc.