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Cytologic‐histologic correlation of nongynecologic cytopathology cases: Separation of determinate from indeterminate cytologic diagnoses for analysis and monitoring of laboratory performance
Author(s) -
Ohori N. Paul,
Schoedel Karen E.,
Rajendiran Swaminathan
Publication year - 2003
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.10214
Subject(s) - cytopathology , indeterminate , medicine , cytology , medical diagnosis , pathology , sampling (signal processing) , surgical pathology , radiology , anatomical pathology , immunohistochemistry , mathematics , filter (signal processing) , computer science , pure mathematics , computer vision
Abstract Much of the literature on the quality‐assurance aspect of cytologic‐histologic correlation (CHC) has focused on gynecologic cytology. For nongynecologic cytopathology, the process is complicated by the use of determinate (positive for malignant cells, negative for malignant cells) and indeterminate (atypical, suspicious, or follicular lesion) diagnostic categories. Here, we illustrate our routine methodology for analyzing CHC data on nongynecologic cytopathology cases by separating determinate from indeterminate cases. A focused list of determinate and indeterminate cytopathology cases with surgical pathology correlation is generated each week. The determinate cases are ascertained as true positive (TP), true negative (TN), false positive (FP), or false negative (TN). The discrepant cases (FP and FN) are investigated to determine the cause (sampling, interpretation, or screening). For indeterminate cases, the surgical pathology outcome (benign, malignant) and suitability of the cytopathology category utilized are reviewed. For the focused period of 4 mo, sensitivity was 70% and specificity was 100%. The most common reason for false‐negative diagnoses was a sampling problem in the cytologic specimen; there were no false‐positive diagnoses. Malignant outcomes for follicular lesion, atypical, and suspicious diagnoses were 29%, 40%, and 76%, respectively. Data derived from regularly performed CHC are useful in reviewing the diagnostic performance of the laboratory. Diagn. Cytopathol. 2003;28:28–34. © 2003 Wiley‐Liss, Inc.