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Fine‐needle aspiration cytology diagnosis of metastatic gastrointestinal stromal tumor in the liver: A report of three cases
Author(s) -
Padilla Catalina,
Saez Amparo,
Català Isabel,
Vidal August,
Garcia Lluis,
Tolosa Filomena,
Andreu F. Javier,
Combalia Neus
Publication year - 2002
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.10191
Subject(s) - gist , cd117 , medicine , stromal tumor , interstitial cell of cajal , fine needle aspiration , pathology , cd34 , immunocytochemistry , stromal cell , immunohistochemistry , biopsy , stem cell , biology , genetics
Gastrointestinal stromal tumor (GIST) is the designation for a major subset of gastrointestinal mesenchymal tumors that histologically, immunocytochemically, and genetically differ from leiomyomas, leiomyosarcomas, and schwannomas. GISTs derive from the interstitial cells of Cajal and, in addition to variable expression of smooth muscle and neural markers, they characteristically express CD34 and CD117. The cytological appearance, including immunocytochemical and mutational analysis of c‐kit gene in primary GIST has been well described. To our knowledge, only two cases of metastatic GIST diagnosed by fine‐needle aspiration (FNA) have been reported. We illustrate three cases of metastatic GIST in the liver. Two cases had no prior history of gastrointestinal tumor and the third case had a 4‐yr previous history of duodenal tumor. Consistent immunocytochemistry and ultrastructual studies supported the diagnosis of GIST. We emphasize that in the appropriate clinical and radiological setting, a confident diagnosis of GIST can be established by FNA of metastatic lesions. Diagn. Cytopathol. 2002;27:298–302. © 2002 Wiley‐Liss, Inc.