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Cytohistologic correlations of 24 malignant peripheral nerve sheath tumor (MPNST) in 17 patients: The Institut Curie experience
Author(s) -
Klijanienko Jerzy,
Caillaud JeanMichel,
Lagacé Réal,
Vielh Philippe
Publication year - 2002
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.10152
Subject(s) - malignant peripheral nerve sheath tumor , medicine , pathology , neurofibroma , neurofibromatosis , sarcoma , synovial sarcoma , nerve sheath neoplasm , leiomyosarcoma , fibrosarcoma
Cytomorphological patterns of malignant peripheral nerve sheath tumor (MPNST) are insufficiently documented in the literature. Cytological and histological specimens in 24 tumors in 17 patients were correlated. The review of the original cytology reports showed that four (16.6%) tumors were correctly diagnosed, eight (33.3%) were diagnosed as sarcoma not otherwise specified, four (16.7%) as fibrosarcoma, three (12.5%) as synovial sarcoma, three (12.5%) as leiomyosarcoma, and one (4.2%) case each as malignant fibrous histiocytoma and rhabdomyosarcoma. At the review tumors were histologically reclassified as well‐differentiated MPNST in 11 (45.9%) cases, anaplastic MPNST in 11 (45.9%) cases, and epithelioid MPNST and malignant Triton tumor in one (4.2%) case each. Cytologically, well‐differentiated MPNST were composed of polymorphous oval to round cells, small spindle‐shaped cells with wavy and comma‐like naked nuclei, and a fibrillary, delicate stroma. Anaplastic MPNST, moreover, were composed of anaplastic giant and polymorphous cells. The malignant Triton tumor was composed of oval to round rhabdomyoblastic cells with eccentric nuclei and the epithelioid MPNST of polymorphous and round, epithelial‐like cells. The cytological diagnosis of MPNST may be difficult, especially in anaplastic tumors. The correlation between the cytological features and the clinical information—origin of the tumor from a nerve trunk, a preexisting neurofibroma, patients with known history of neurofibromatosis 1—could be indicative of an MPNST diagnosis. Diagn. Cytopathol. 2002;27:103–108. © 2002 Wiley‐Liss, Inc.