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Cytological grading, apoptosis, and Bcl‐2 protein expression in breast cancer
Author(s) -
Hemachandran Manikkapurath,
Nijhawan Raje,
Joshi Kusum
Publication year - 2002
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.10105
Subject(s) - medicine , grading (engineering) , concordance , cytology , breast cancer , prospective cohort study , pathology , mastectomy , carcinoma , cancer , biology , ecology
A prospective study was conducted on 27 cases of infiltrating duct carcinoma of breast diagnosed by fine‐needle aspirate cytology (FNAC), subjected to mastectomy following the FNA diagnosis. Cytological grading, Bcl‐2 score, and quantification of apoptotic cell count were done on FNA material. Next, the carcinomas were graded on the corresponding histopathological sections. The overall concordance between cytological and histological gradings was 77.7%, with maximum concordance in Grade I tumors and minimum in Grade II. The mean apoptotic rates were 0.59 ± 0.722, 2.11 ± 0.707, and 2.95 ± 0.854 in Grades I, II, and III, respectively. Similarly Bcl‐2 scores were 1.36 ± 0.82, 0.22 ± 0.13, and 0.14 ± 0.116, in Grades I, II, and III lesions, respectively. When the cytological grade was correlated with histological grade alone, and subsequently along with Bcl‐2 scores and apoptotic rates, there was a significant improvement from 0.662–0.713 ( P value, 0.001). Diagn. Cytopathol. 2002;26:356–359. © 2002 Wiley‐Liss, Inc.