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Anaplastic T large cell lymphoma diagnosed by exfoliative cytology in a post renal transplant patient
Author(s) -
Treaba Diana,
Assad Lina,
Goldberg Cathryn,
Loew Jerome,
Reddy Vijaya B.,
Kluskens Larry,
Gattuso Paolo
Publication year - 2002
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.10100
Subject(s) - medicine , lymphoproliferative disorders , immunosuppression , pathology , lymphoma , anaplastic large cell lymphoma , transplantation , incidence (geometry) , t cell lymphoma , gastroenterology , physics , optics
Abstract In the last two decades posttransplant lymphoproliferative disorders (PTLDs) have been recognized as a complication of organ transplantation with immunosuppression. The reported incidence of PTLDs in renal transplant patients ranges between 0.3–3% (Birkeland et al., Transplantation 1999;67:876–881). In contrast to the reported incidence of PTLDs in post bone marrow transplant, it is 1% in HLA‐matched recipients and up to 20% in HLA mismatched T‐cell depleted bone marrow recipients (Curtis et al., Blood 1996;94:2208–2216).2 In cardiac transplant recipients the reported incidence of PTLDs is between 1.8–9.8 (Mihalov et al., Clin Transplant 1996;10:248–255). PTLDs are predominately extranodal. They have varied morphologic patterns and clonality, but almost all are associated with Epstein‐Barr virus (EBV). The vast majority are of B cell lineage; only about 10% are of T‐cell origin. We report a T‐cell anaplastic large cell lymphoma (ALCL) presenting with bilateral pleural effusion and liver involvement in a renal transplant recipient. Diagn. Cytopathol. 2002;27:35–37. © 2002 Wiley‐Liss, Inc.