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Fine‐needle aspiration cytology of phyllodes tumors
Author(s) -
Jayaram Gita,
Sthaneshwar Pavai
Publication year - 2002
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.10085
Subject(s) - pathology , medicine , stroma , stromal cell , cytopathology , cytology , mesenchymal stem cell , fine needle aspiration , phyllodes tumor , epithelium , differential diagnosis , biopsy , immunohistochemistry
Breast lesions with a significant spindle cell or mesenchymal component are not commonly encountered in fine‐needle aspiration (FNA) cytologic material and include a heterologous variety of benign and malignant conditions, with phyllodes tumors (PTs) being the foremost differential diagnostic consideration. This study comprises 28 tumors diagnosed histologically as PT in which FNAC material was available for review. Histological sections and cytological smears from these cases were retrieved and subjected to detailed morphological review. Cytological parameters assessed included ratio of stroma to epithelium, pattern characteristics and cytological characteristics of the stromal, and epithelial components and the background cells. Large and hypercellular stroma fragments, dissociated spindle and plump stromal cells, often accompanied by large, folded sheets of epithelium were cytological features that characterized PT. Smears from malignant PT showed predominantly or solely mesenchymal components. FNAC was a highly reliable procedure for the diagnosis of PT, giving an accuracy rate of 92.8%. Diagn. Cytopathol. 2002;26:222–227. © 2002 Wiley‐Liss, Inc.