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Clear‐cell sarcoma diagnosis by fine‐needle aspiration: Cytologic, histologic, and ultrastructural features; potential pitfalls; and literature review
Author(s) -
Tong Tommy R.,
Chow Tatchong,
Chan Olivia Waihing,
Lee Kamcheong,
Yeung Saihung,
Lam Angus,
Yu Chikin
Publication year - 2002
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.10081
Subject(s) - medicine , cytology , pathology , cytopathology , fine needle aspiration , ultrastructure , sarcoma , fine needle aspiration cytology , cytological techniques , biopsy
Abstract A definitive diagnosis of clear‐cell sarcoma of soft parts (CCSSP) is possible by fine‐needle aspiration (FNA) biopsy alone. The aspirates are markedly cellular, consisting predominantly of discohesive cells but also of cohesive cells. The cytoplasm is eosinophilic and eccentric. The nuclei are round and contain macronucleoli. CCSSP should be considered when FNA of a soft‐tissue tumor shows uncharacteristically high cellularity and relatively uniform cells with macronucleoli. Cohesion of some tumor cells does not rule out CCSSP. Melanin pigment and cytoplasmic clearing are infrequent and not necessary for the diagnosis. Sufficient material should always be procured for immunohistochemical studies on the cell block. Seven other cases are found in the literature, all correctly diagnosed by FNA. Although it is rare, CCSSP is a highly malignant tumor that can be diagnosed readily by FNA without resorting to incisional biopsy. Diagn. Cytopathol. 2002;26:174–180; DOI 10.1002/dc.10081 © 2002 Wiley‐Liss, Inc.