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Application of adjunct techniques in cytologic material in the diagnosis of rhabdomyosarcoma: Case report and review of the literature
Author(s) -
Bhattacharya Baishali,
Sariya Dinesh,
Reddy Vijaya B.,
Kluskens Larry,
Gould Victor E.,
Gattuso Paolo
Publication year - 2002
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.10069
Subject(s) - desmin , rhabdomyosarcoma , pathology , medicine , cytology , immunostaining , ultrastructure , immunohistochemistry , myosin , pleural effusion , embryonal rhabdomyosarcoma , vimentin , anatomy , sarcoma , radiology , biology , microbiology and biotechnology
A 4½‐yr‐old female presented with right‐sided pleural effusion and a retroperitoneal mass. Cytologic analysis of the pleural fluid yielded malignant small round blue cells, which were noncohesive, 3–4 times the size of lymphocytes. The malignant cells had hyperchromatic, pleomorphic nuclei with moderate amounts of vacuolated cytoplasm. A few fiber‐shaped cells were also seen. Immunostains for desmin, muscle‐specific actin were positive; ultrastructural findings of thick and thin actin‐myosin filaments confirmed the diagnosis of embryonal rhabdomyosarcoma. This case illustrates the importance of performing appropriate immunohistochemical stains and ultrastructural studies on cytological material to arrive at a definitive diagnosis. Diagn. Cytopathol. 2002;26:384–386. © 2002 Wiley‐Liss, Inc.