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Fine‐needle aspiration cytology and differential diagnoses of fibrolamellar hepatocellular carcinoma metastatic to the mediastinum: Case report
Author(s) -
Sarode Venetia R.,
Castellani Rudy,
Post Anthony
Publication year - 2002
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.10047
Subject(s) - medicine , fine needle aspiration , differential diagnosis , cytology , pathology , metastatic carcinoma , mediastinum , biopsy , hepatocellular carcinoma , cytopathology , radiology , carcinoma
We report a case of fibrolamellar hepatocellular carcinoma (FL‐HCC) that metastasized to the posterior mediastinum. The diagnosis was made on fine‐needle aspiration biopsy (FNAB). The cytologic features were characterized by the presence of large, dishesive, polygonal cells with granular cytoplasm and well‐defined cell outlines resembling oncocytes. Groups of neoplastic hepatocytes containing bile pigment were also noted. The diagnosis of FL‐HCC in a metastatic site can pose diagnostic challenges on FNAB. The cytologic features overlap with a variety of tumors that have oncocytic features and also with melanoma and paraganglioma. Recognition of specific cytologic features of FL‐HCC can facilitate accurate diagnosis in a metastatic site. The cytologic findings and differential diagnoses of FL‐HCC that metastasized to the posterior mediastinum are discussed. Diagn. Cytopathol. 2002;26:95–98; DOI 10.1002/dc.10047 © 2002 Wiley‐Liss, Inc.