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Role of flow cytometry in the diagnosis of lymphadenopathy in children
Author(s) -
Chen Yu,
Savargaonkar Pratima,
Fuchs Alexander,
Wasserman Patricia
Publication year - 2002
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.10027
Subject(s) - medicine , lymphoma , immunophenotyping , biopsy , fine needle aspiration , cervical lymphadenopathy , radiology , pathology , flow cytometry , immunology , disease
To evaluate the combination of fine‐needle aspiration (FNA) and flow cytometric immunophenotyping (FCI) in the diagnosis of lymphadenopathy in children, we reviewed a total of 71 FNA specimens from pediatric patients with persistent lymphadenopathy. Two cases were deemed inadequate. In the remaining 69 cases, 54 (78%) were diagnosed as benign lesions, 9 (13%) as Hodgkin's lymphoma, 4 (6%) as non‐Hodgkin's lymphoma or leukemic infiltrate, and 2 as metastatic tumors. Of the 69 cases, 25 cases (38%) were diagnosed based on cytomorphology alone, 30 (43%) by combined cytomorphology and FCI, and 19 (28%) by surgical biopsy. In conclusion, FNA is an easy, safe, and reliable procedure in the diagnosis of lymphadenopathy in children. In difficult cases, FCI can be used to exclude non‐Hodgkin's lymphomas. Diagn. Cytopathol. 2002;26:5–9. © 2002 Wiley‐Liss, Inc.