Open AccessLate occurrence of malignant post‐transplant lymphoproliferative disorder (PTLD) presenting with severe acute renal failure
Author(s) -
Ziari Mohammadbagher,
Kudva Ganesh C.,
SalinasMadrigal Luis,
Cortese Cherise,
Garvin Paul,
Osman Medhat M.,
Bastani Bahar
Publication year - 2007
Publication title -
dialysis & transplantation
Language(s) - English
Resource type - Journals
eISSN - 1932-6920
pISSN - 0090-2934
DOI - 10.1002/dat.20133
Subject(s) - medicine , post transplant lymphoproliferative disorder , chemotherapy , rituximab , lymphoma , peritoneal dialysis , kidney , lymphoproliferative disorders , kidney disease , dialysis , kidney transplantation , biopsy , surgery , gastroenterology
We report the case of a 63‐year‐old man who presented with severe acute renal failure requiring dialysis 17 years after a successful renal transplant of a kidney from his daughter. Transplant kidney biopsy revealed post‐transplant lymphoproliferative disorder‐large B‐cell lymphoma. A PET scan revealed widespread disease, particularly involving the transplanted kidney. The patient responded rapidly to chemotherapy with VACOP‐B and rituximab, with a complete resolution of renal failure and of the findings from the PET scan. The patient was in remission for 6 months, while on chemotherapy, before he was found to have recurrence of the disease in cervical lymph nodes and died 1 month later with normal kidney function.