Open AccessAssociations of the Lifestyle for Brain Health index with longitudinal cognition and brain amyloid beta in clinically unimpaired older adults: Findings from the Wisconsin Registry for Alzheimer's Prevention
Author(s) -
Cody Karly A.,
Koscik Rebecca L.,
Erickson Claire M.,
Berman Sara E.,
Jonaitis Erin M.,
Williams Victoria J.,
Mueller Kimberly D.,
Christian Bradley T.,
Chin Nathanial A.,
Clark Lindsay R.,
Betthauser Tobey J.,
Johnson Sterling C.
Publication year - 2022
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1002/dad2.12351
Subject(s) - dementia , cognitive decline , cognition , apolipoprotein e , gerontology , longitudinal study , medicine , alzheimer's disease , effects of sleep deprivation on cognitive performance , disease , psychology , psychiatry , pathology
Modifiable health and lifestyle factors increase risk of dementia, but whether modifiable factors, when measured in late‐midlife, impact the emergence or progression of Alzheimer's disease (AD) pathophysiologic or cognitive changes remains unresolved. Methods In initially cognitively unimpaired, late middle‐aged participants ( N = 1215; baseline age, M [standard deviation] = 59.3 [6.7] years) from the Wisconsin Registry for Alzheimer's Prevention (WRAP), we investigated the influence of the Lifestyle for Brain Health (LIBRA) index, a lifestyle‐based dementia risk score, on AD‐related cognitive trajectories and amyloid beta (Aβ) plaque accumulation. Results Overall, lower baseline LIBRA, denoting healthier lifestyle and lower dementia risk, was related to better overall cognitive performance, but did not moderate apolipoprotein E ε4 or Aβ‐related longitudinal cognitive trajectories. LIBRA was not significantly associated with Aβ accumulation or estimated age of Aβ onset. Discussion In WRAP, late‐midlife LIBRA scores were related to overall cognitive performance, but not AD‐related cognitive decline or Aβ accumulation in the preclinical timeframe. HighlightsThe Lifestyle for Brain Health (LIBRA) index was associated with cognitive performance in late‐midlife. LIBRA did not moderate apolipoprotein E ε4 or amyloid‐related cognitive decline. LIBRA was not associated with the onset or accumulation of amyloid plaques.