Open AccessPlasma biomarkers predict cognitive trajectories in an ethnoracially and clinically diverse cohort: Mediation with hippocampal volume
Author(s) -
Sapkota Shraddha,
Erickson Kelsey,
Harvey Danielle,
TomaszewskiFarias Sarah E.,
Olichney John M.,
Johnson David K.,
Dugger Brittany N.,
Mungas Dan M.,
Fletcher Evan,
Maillard Pauline,
Seshadri Sudha,
Satizabal Claudia L.,
Kautz Tiffany,
Parent Danielle,
Tracy Russell P.,
Maezawa Izumi,
Jin LeeWay,
DeCarli Charles
Publication year - 2022
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1002/dad2.12349
Subject(s) - neurodegeneration , mediation , episodic memory , cognition , medicine , association (psychology) , cognitive decline , cohort , oncology , psychology , hippocampal formation , biomarker , hippocampus , neuroscience , disease , gerontology , dementia , biology , genetics , psychotherapist , political science , law
We examine whether the association between key plasma biomarkers (amyloid β [aβ] 42/40, total tau (t‐tau), neurofilament light [NfL]) and cognitive trajectories (executive function [EF] and episodic memory [EM]) is mediated through neurodegeneration. Methods All participants were recruited from the University of California, Davis‐Alzheimer's Disease Research Center ( n = 473; baseline age range = 49—95 years, 60% women). We applied an accelerated longitudinal design to test latent growth models for EF and EM, and path and mediation analyses. Age was centered at 75 years, and all models were adjusted for sex, education, and ethnicity. Results HV differentially mediated the association aβ 42/40 and NfL on EF and EM level and change. Hippocampal volume (HV) did not mediate the association between t‐tau and cognitive performance. Discussion Neurodegeneration as represented with HV selectively mediates the association between key non‐invasive plasma biomarkers and cognitive trajectories in an ethnoracially and clinically diverse community‐based sample.