Open AccessAssociation between serum urate and CSF markers of Alzheimer's disease pathology in a population‐based sample of 70‐year‐olds
Author(s) -
Fatima Tahzeeb,
Jacobsson Lennart T.H.,
Kern Silke,
Zettergren Anna,
Blennow Kaj,
Zetterberg Henrik,
Johansson Lena,
Dehlin Mats,
Skoog Ingmar
Publication year - 2021
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1002/dad2.12241
Subject(s) - apolipoprotein e , cerebrospinal fluid , pathophysiology , medicine , endocrinology , dementia , disease , apolipoprotein b , amyloid (mycology) , uric acid , alzheimer's disease , population , allele , pathology , psychology , gastroenterology , chemistry , cholesterol , biochemistry , gene , environmental health
The relationship between urate and biomarkers for Alzheimer's disease (AD) pathophysiology has not been investigated. Methods We examined whether serum concentration of urate was associated with cerebrospinal fluid biomarkers, amyloid beta (Aβ) 42 , Aβ 40 , phosphorylated tau (p‐tau), total tau (t‐tau), neurofilament light (NfL), and Aβ 42 /Aβ 40 ratio, in cognitively unimpaired 70‐year‐old individuals from Gothenburg, Sweden. We also evaluated whether possible associations were modulated by the apolipoprotein E ( APOE ) ε4 allele. Results Serum urate was positively associated with Aβ 42 in males (β = 0.55 pg/mL, P = .04). There was a positive urate– APOE ε4 interaction (1.24 pg/mL, P interaction = .02) in relation to Aβ 42 association. The positive urate and Aβ 42 association strengthened in male APOE ε4 carriers (β = 1.28 pg/mL, P = .01). Discussion The positive association between urate and Aβ 42 in cognitively healthy men may suggest a protective effect of urate against deposition of amyloid protein in the brain parenchyma, and in the longer term, maybe against AD dementia.