Open AccessHippocampal subfield volumes are associated with verbal memory after first‐ever ischemic stroke
Author(s) -
Khlif Mohamed Salah,
Bird Laura J.,
Restrepo Carolina,
Khan Wasim,
Werden Emilio,
EgorovaBrumley Natalia,
Brodtmann Amy
Publication year - 2021
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1002/dad2.12195
Subject(s) - hippocampal formation , verbal memory , stroke (engine) , cognition , verbal learning , psychology , hippocampus , memory impairment , neuroscience , audiology , medicine , mechanical engineering , engineering
Hippocampal subfield volumes are more closely associated with cognitive impairment than whole hippocampal volume in many diseases. Both memory and whole hippocampal volume decline after stroke. Understanding the subfields’ temporal evolution could reveal valuable information about post‐stroke memory. Methods We sampled 120 participants (38 control, 82 stroke), with cognitive testing and 3T‐MRI available at 3 months and 3 years, from the Cognition and Neocortical Volume after Stroke (CANVAS) study. Verbal memory was assessed using the Hopkins Verbal Learning Test‐Revised. Subfields were delineated using FreeSurfer. We used partial Pearson's correlation to assess the associations between subfield volumes and verbal memory scores, adjusting for years of education, sex, and stroke side. Results The left cornu ammonis areas 2/3 and hippocampal tail volumes were significantly associated with verbal memory 3‐month post‐stroke. At 3 years, the associations became stronger and involved more subfields. Discussion Hippocampal subfield volumes may be a useful biomarker for post‐stroke cognitive impairment.