Open AccessSelective hippocampal subfield volume reductions in World Trade Center responders with cognitive impairment
Author(s) -
Deri Yael,
Clouston Sean A. P.,
DeLorenzo Christine,
Gardus John D.,
Horton Megan,
Tang Cheuk,
Pellecchia Alison C.,
SantiagoMichels Stephanie,
Carr Melissa A.,
Gandy Sam,
Sano Mary,
Bromet Evelyn J.,
Lucchini Roberto G.,
Luft Benjamin J.
Publication year - 2021
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1002/dad2.12165
Subject(s) - hippocampal formation , world trade center , confounding , dementia , hippocampus , medicine , cognitive impairment , cognition , magnetic resonance imaging , brain size , audiology , psychology , neuroscience , radiology , disease , archaeology , terrorism , history
The objective of this study was to investigate associations between dementia in World Trade Center (WTC) responders and in vivo volumetric measures of hippocampal subfield volumes in WTC responders at midlife. Methods A sample of 99 WTC responders was divided into dementia and unimpaired groups. Participants underwent structural T1‐weighted magnetic resonance imaging. Volumetric measures included the overall hippocampus and eight subfields. Regression models examined volumetric measure of interest adjusting for confounders including intracranial volume. Results Dementia was associated with smaller hippocampal volume and with reductions across hippocampal subfields. Smaller hippocampal subfield volumes were associated with longer cumulative time worked at the WTC. Domain‐specific cognitive performance was associated with lower volumetric measures across hippocampal subregions. Conclusions This is the first study to investigate hippocampal subfield volumes in a sample of WTC responders at midlife. Selective hippocampal subfield volume reductions suggested abnormal cognition that were associated with WTC exposure duration.