Open AccessBody weight changes and longitudinal associations with cognitive decline among community‐dwelling older adults
Author(s) -
Eymundsdottir Hrafnhildur,
Ramel Alfons,
Geirsdottir Olof G.,
Skuladottir Sigrun S.,
Gudmundsson Larus S.,
Jonsson Palmi V.,
Gudnason Vilmundur,
Launer Lenore,
Jonsdottir Maria K.,
Chang Milan
Publication year - 2021
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1002/dad2.12163
Subject(s) - cognition , dementia , logistic regression , cognitive decline , longitudinal study , gerontology , medicine , demography , weight loss , effects of sleep deprivation on cognitive performance , weight change , psychology , obesity , psychiatry , disease , pathology , sociology
We aim to investigate the longitudinal associations between changes in body weight (BW) and declines in cognitive function and risk of mild cognitive impairment (MCI)/dementia among cognitively normal individuals 65 years or older. Methods Data from the Age Gene/Environment Susceptibility‐Reykjavik Study (AGES‐Reykjavik Study) including 2620 participants, were examined using multiple logistic regression models. Cognitive function included speed of processing (SP), executive function (EF), and memory function (MF). Changes in BW were classified as; weight loss (WL), weight gain (WG), and stable weight (SW). Results Mean follow‐up time was 5.2 years and 61.3% were stable weight. Participants who experienced WL (13.4%) were significantly more likely to have declines in MF and SP compared to the SW group. Weight changes were not associated with EF. WL was associated with a higher risk of MCI, while WG (25.3%) was associated with a higher dementia risk, when compared to SW. Discussion Significant BW changes in older adulthood may indicate impending changes in cognitive function.