Open AccessAssociation between neurite metrics and tau/inflammatory pathology in Alzheimer's disease
Author(s) -
Sone Daichi,
Shigemoto Yoko,
Ogawa Masayo,
Maikusa Norihide,
Okita Kyoji,
Takano Harumasa,
Kato Koichi,
Sato Noriko,
Matsuda Hiroshi
Publication year - 2020
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1002/dad2.12125
Subject(s) - pittsburgh compound b , neurite , positron emission tomography , neurodegeneration , neuroscience , magnetic resonance imaging , neuroimaging , neuroinflammation , amyloid (mycology) , cognitive impairment , medicine , cognition , psychology , disease , pathology , chemistry , radiology , biochemistry , in vitro
Abstract Introduction The molecular mechanism of neurodegeneration, including tau and neurite complexity, is an important topic in Alzheimer's disease (AD) research. Methods We recruited 27 amyloid‐positive individuals identified through 11 C‐Pittsburgh compound B (PiB) positron emission tomography (PET) and 31 amyloid‐negative individuals with normal cognition. All participants underwent 11 C‐PiB and 18 F‐THK5351 PET and magnetic resonance imaging (MRI) with neurite orientation dispersion and density imaging (NODDI) protocol. The neurite density index (NDI), orientation dispersion index (ODI), and PET images were analyzed to calculate voxel‐wise correlations among the imaging modalities and correlations with cognitions. Results In the amyloid‐positive participants, there were significant negative correlations between 18 F‐THK5351 and NDI and between 18 F‐THK5351 and ODI. The bilateral mesial and lateral temporal lobes were mainly involved. Regarding cognition, 18 F‐THK5351 showed more marked associations with all cognitive domains than the other modalities. Discussion Tau and neuroinflammation in AD may reduce the neurite density and orientation dispersion, particularly in the mesial and lateral temporal lobes.