Open AccessWhite matter microstructure disruption in early stage amyloid pathology
Author(s) -
Collij Lyduine E.,
Ingala Silvia,
Top Herwin,
Wottschel Viktor,
Stickney Kristine E.,
Tomassen Jori,
Konijnenberg Elles,
ten Kate Mara,
Sudre Carole,
Lopes Alves Isadora,
Yaqub Maqsood M.,
Wink Alle Meije,
Van ‘t Ent Dennis,
Scheltens Philip,
Berckel Bart N.M.,
Visser Pieter Jelle,
Barkhof Frederik,
Braber Anouk Den
Publication year - 2021
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1002/dad2.12124
Subject(s) - fractional anisotropy , amyloid (mycology) , white matter , corpus callosum , diffusion mri , pathology , positron emission tomography , magnetic resonance imaging , psychology , medicine , nuclear medicine , radiology
Abstract Introduction Amyloid beta (Aβ) accumulation is the first pathological hallmark of Alzheimer's disease (AD), and it is associated with altered white matter (WM) microstructure. We aimed to investigate this relationship at a regional level in a cognitively unimpaired cohort. Methods We included 179 individuals from the European Medical Information Framework for AD (EMIF‐AD) preclinAD study, who underwent diffusion magnetic resonance (MR) to determine tract‐level fractional anisotropy (FA); mean, radial, and axial diffusivity (MD/RD/AxD); and dynamic [ 18 F]flutemetamol) positron emission tomography (PET) imaging to assess amyloid burden. Results Regression analyses showed a non‐linear relationship between regional amyloid burden and WM microstructure. Low amyloid burden was associated with increased FA and decreased MD/RD/AxD, followed by decreased FA and increased MD/RD/AxD upon higher amyloid burden. The strongest association was observed between amyloid burden in the precuneus and body of the corpus callosum (CC) FA and diffusivity (MD/RD) measures. In addition, amyloid burden in the anterior cingulate cortex strongly related to AxD and RD measures in the genu CC. Discussion Early amyloid deposition is associated with changes in WM microstructure. The non‐linear relationship might reflect multiple stages of axonal damage.