Open AccessAPOE ε 4 and resting‐state functional connectivity in racially/ethnically diverse older adults
Author(s) -
Turney Indira C.,
Chesebro Anthony G.,
Rentería Miguel Arce,
Lao Patrick J.,
Beato Juliet M.,
Schupf Nicole,
Mayeux Richard,
Manly Jennifer J.,
Brickman Adam M.
Publication year - 2020
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1002/dad2.12094
Subject(s) - apolipoprotein e , ethnic group , gerontology , allele , resting state fmri , medicine , default mode network , psychology , functional connectivity , genetics , neuroscience , biology , gene , sociology , disease , anthropology
Numerous neuroimaging studies demonstrated an association between the apolipoprotein E (APOE) ε 4 allele and resting‐state functional connectivity (rsFC) of regions within the default mode network (DMN), both in healthy populations and patients with AD. It remains unclear whether the APOE ε 4 allele differentially affects the brain's functional network architecture across race/ethnicity. Methods We investigated rsFC within DMN subsystems in 170 APOE ε 4 carriers compared to 387 APOE ε 4 non‐carriers across three major racial/ethnic groups, including non‐Hispanic Whites (n = 166), non‐Hispanic Blacks (n = 185), and Hispanics (n = 206) from the Washington Heights‐Inwood Columbia Aging Project. Results Compared to APOE ε 4 non‐carriers, APOE ε 4 carriers had lower rsFC in temporal DMN, but only in non‐Hispanic Whites. Non‐Hispanic Black and Hispanic APOE ε 4 carriers had slightly higher or similar rsFC compared with non‐Hispanic White APOE ε 4 non‐carriers. Discussion These findings suggest that APOE ε 4 modulates DMN rsFC differently in non‐Hispanic Whites compared with non‐Hispanic Blacks and Hispanics.