Open AccessSex differences in risk of Alzheimer's disease in adults with Down syndrome
Author(s) -
Lai Florence,
Mhatre Pooja G.,
Yang Yuchen,
Wang MeiCheng,
Schupf Nicole,
Rosas H. Diana
Publication year - 2020
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1002/dad2.12084
Subject(s) - biostatistics , public health , medical school , gerontology , medicine , family medicine , epidemiology , general hospital , columbia university , neurology , library science , psychiatry , sociology , medical education , media studies , nursing , computer science
Adults with Down syndrome (DS) older than 40 have Alzheimer's disease (AD) neuropathology and high risk for dementia, but little is known about the relationship of sex to AD risk in this population. Methods Using nonparametric methods and Cox proportional hazards models we analyzed differences in incidence of dementia, by sex, presence of an apolipoprotein E ( APOE ) ε4 or ε2 allele, and dementia duration and decline in 246 adults over 40 with DS. Results There was no significant sex difference in risk of AD or rate of cognitive decline. APOE ε4 allele significantly increased risk of AD irrespective of sex. No significant interactions were found between sex and APOE status on AD risk. Among those who died, dementia duration was significantly longer in women. Discussion This study showed no effect of sex nor interaction between sex and APOE for risk of AD in adults with DS; however, women had longer dementia duration.