Open AccessNutritional status and structural brain changes in Alzheimer's disease: The NUDAD project
Author(s) -
Verhaar Barbara J.H.,
Leeuw Francisca A.,
Doorduijn Astrid S.,
Fieldhouse Jay L.P.,
Rest Ondine,
Teunissen Charlotte E.,
Berckel Bart N.M.,
Barkhof Frederik,
Visser Marjolein,
Schueren Marian A.E.,
Scheltens Philip,
Kester Maartje I.,
Muller Majon,
Flier Wiesje M.
Publication year - 2020
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1002/dad2.12063
Subject(s) - dementia , body mass index , medicine , magnetic resonance imaging , atrophy , waist , cognitive reserve , cognitive decline , alzheimer's disease , gerontology , brain size , disease , cognition , mass index , psychiatry , radiology
Weight loss is associated with higher mortality and progression of cognitive decline, but its associations with magnetic resonance imaging (MRI) changes related to Alzheimer's disease (AD) are unknown. Methods We included 412 patients from the NUDAD project, comprising 129 with AD dementia, 107 with mild cognitive impairment (MCI), and 176 controls. Associations between nutritional status and MRI measures were analyzed using linear regression, adjusted for age, sex, education, cognitive functioning, and cardiovascular risk factors. Results Lower body mass index (BMI), fat mass (FM), and fat free mass index were associated with higher medial temporal atrophy (MTA) scores. Lower BMI, FM, and waist circumference were associated with more microbleeds. Stratification by diagnosis showed that the observed associations with microbleeds were only significant in MCI. Discussion Lower indicators of nutritional status were associated with more MTA and microbleeds, with largest effect sizes in MCI.