Open AccessClearance of interstitial fluid (ISF) and CSF (CLIC) group—part of Vascular Professional Interest Area (PIA)
Author(s) -
Carare Roxana O.,
Aldea Roxana,
Agarwal Nivedita,
Bacskai Brian J.,
Bechman Ingo,
Boche Delphine,
Bu Guojun,
Bulters Diederik,
Clemens Alt,
Counts Scott E.,
Leon Mony,
Eide Per K.,
Fossati Silvia,
Greenberg Steven M.,
Hamel Edith,
Hawkes Cheryl A.,
KoronyoHamaoui Maya,
Hainsworth Atticus H.,
Holtzman David,
Ihara Masafumi,
Jefferson Angela,
Kalaria Raj N.,
Kipps Christopher M.,
Kanninen Katja M.,
Lein Ville,
McLaurin JoAnne,
Miners Scott,
Malm Tarja,
Nicoll James A. R.,
Piazza Fabrizio,
Paul Gesine,
Rich Steven M.,
Saito Satoshi,
Shih Andy,
Scholtzova Henrieta,
Snyder Heather,
Snyder Peter,
Thormodsson Finnbogi Rutur,
Veluw Susanne J.,
Weller Roy O.,
Werring David J.,
Wilcock Donna,
Wilson Mark R.,
Zlokovic Berislav V.,
Verma Ajay
Publication year - 2020
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1002/dad2.12053
Subject(s) - medicine , university hospital , library science , gerontology , computer science
Abstract Two of the key functions of arteries in the brain are (1) the well‐recognized supply of blood via the vascular lumen and (2) the emerging role for the arterial walls as routes for the elimination of interstitial fluid (ISF) and soluble metabolites, such as amyloid beta (Aβ), from the brain and retina. As the brain and retina possess no conventional lymphatic vessels, fluid drainage toward peripheral lymph nodes is mediated via transport along basement membranes in the walls of capillaries and arteries that form the intramural peri‐arterial drainage (IPAD) system. IPAD tends to fail as arteries age but the mechanisms underlying the failure are unclear. In some people this is reflected in the accumulation of Aβ plaques in the brain in Alzheimer's disease (AD) and deposition of Aβ within artery walls as cerebral amyloid angiopathy (CAA). Knowledge of the dynamics of IPAD and why it fails with age is essential for establishing diagnostic tests for the early stages of the disease and for devising therapies that promote the clearance of Aβ in the prevention and treatment of AD and CAA. This editorial is intended to introduce the rationale that has led to the establishment of the Clearance of Interstitial Fluid (ISF) and CSF (CLIC) group, within the Vascular Professional Interest Area of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment.