Open AccessDiagnosis of prodromal and Alzheimer's disease dementia in adults with Down syndrome using neuropsychological tests
Author(s) -
Benejam Bessy,
Videla Laura,
Vilaplana Eduard,
Barroeta Isabel,
CarmonaIragui Maria,
Altuna Miren,
Valldeneu Silvia,
Fernandez Susana,
Giménez Sandra,
Iulita Florencia,
Garzón Diana,
Bejanin Alexandre,
BartrésFaz David,
Videla Sebastià,
Alcolea Daniel,
Blesa Rafael,
Lleó Alberto,
Fortea Juan
Publication year - 2020
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1002/dad2.12047
Subject(s) - dementia , neuropsychology , psychology , population , receiver operating characteristic , neuropsychological assessment , cohort , neuropsychological test , normative , alzheimer's disease , audiology , clinical psychology , psychiatry , medicine , cognition , disease , philosophy , environmental health , epistemology
We aimed to define prodromal Alzheimer's disease (AD) and AD dementia using normative neuropsychological data in a large population‐based cohort of adults with Down syndrome (DS). Methods Cross‐sectional study. DS participants were classified into asymptomatic, prodromal AD and AD dementia, based on neurologist's judgment blinded to neuropsychological data (Cambridge Cognitive Examination for Older Adults with Down's syndrome [CAMCOG‐DS] and modified Cued Recall Test [mCRT]). We compared the cutoffs derived from the normative data in young adults with DS to those from receiver‐operating characteristic curve (ROC) analysis. Results Diagnostic performance of the CAMCOG‐DS and modified Cued Recall Test (mCRT) in subjects with mild and moderate levels of intellectual disability (ID) was high, both for diagnosing prodromal AD and AD dementia (area under the curve [AUC] 0.73–0.83 and 0.90–1, respectively). The cutoffs derived from the normative data were similar to those derived from the ROC analyses. Discussion Diagnosing prodromal AD and AD dementia in DS with mild and moderate ID using population norms for neuropsychological tests is possible with high diagnostic accuracy.