Open AccessProteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium–Down Syndrome (ABC–DS) study
Author(s) -
Petersen Melissa E.,
Zhang Fan,
Schupf Nicole,
KrinskyMcHale Sharon J.,
Hall James,
Mapstone Mark,
Cheema Amrita,
Silverman Wayne,
Lott Ira,
Rafii Michael S.,
Handen Benjamin,
Klunk William,
Head Elizabeth,
Christian Brad,
Foroud Tatiana,
Lai Florence,
Rosas H. Diana,
Zaman Shahid,
Ances Beau M.,
Wang MeiCheng,
Tycko Benjamin,
Lee Joseph H.,
O'Bryant Sid
Publication year - 2020
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1002/dad2.12039
Subject(s) - biomarker , cognitive impairment , medicine , down syndrome , alzheimer's disease , area under the curve , gastroenterology , amyloid beta , interleukin 6 , oncology , endocrinology , disease , chemistry , biochemistry , inflammation , psychiatry
Previously generated serum and plasma proteomic profiles were examined among adults with Down syndrome (DS) to determine whether these profiles could discriminate those with mild cognitive impairment (MCI‐DS) and Alzheimer's disease (DS‐AD) from those cognitively stable (CS). Methods Data were analyzed on n = 305 (n = 225 CS; n = 44 MCI‐DS; n = 36 DS‐AD) enrolled in the Alzheimer's Biomarker Consortium–Down Syndrome (ABC–DS). Results Distinguishing MCI‐DS from CS, the serum profile produced an area under the curve (AUC) = 0.95 (sensitivity [SN] = 0.91; specificity [SP] = 0.99) and an AUC = 0.98 (SN = 0.96; SP = 0.97) for plasma when using an optimized cut‐off score. Distinguishing DS‐AD from CS, the serum profile produced an AUC = 0.93 (SN = 0.81; SP = 0.99) and an AUC = 0.95 (SN = 0.86; SP = 1.0) for plasma when using an optimized cut‐off score. AUC remained unchanged to slightly improved when age and sex were included. Eotaxin3, interleukin (IL)‐10, C‐reactive protein, IL‐18, serum amyloid A , and FABP3 correlated fractions at r 2 > = 0.90. Discussion Proteomic profiles showed excellent detection accuracy for MCI‐DS and DS‐AD.