Open AccessDown syndrome: Distribution of brain amyloid in mild cognitive impairment
Author(s) -
Keator David B.,
Phelan Michael J.,
Taylor Lisa,
Doran Eric,
KrinskyMcHale Sharon,
Price Julie,
Ballard Erin E.,
Kreisl William C.,
Hom Christy,
Nguyen Dana,
Pulsifer Margaret,
Lai Florence,
Rosas Diana H.,
Brickman Adam M.,
Schupf Nicole,
Yassa Michael A.,
Silverman Wayne,
Lott Ira T.
Publication year - 2020
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1002/dad2.12013
Subject(s) - posterior cingulate , dementia , positron emission tomography , amyloid (mycology) , psychology , cognitive impairment , pittsburgh compound b , longitudinal study , neuroscience , cognition , neuroimaging , audiology , medicine , cardiology , pathology , disease
Down syndrome (DS) is associated with a higher risk of dementia. We hypothesize that amyloid beta (Aβ) in specific brain regions differentiates mild cognitive impairment in DS (MCI‐DS) and test these hypotheses using cross‐sectional and longitudinal data. Methods 18F‐AV‐45 (florbetapir) positron emission tomography (PET) data were collected to analyze amyloid burden in 58 participants clinically classified as cognitively stable (CS) or MCI‐DS and 12 longitudinal CS participants. Results The study confirmed our hypotheses of increased amyloid in inferior parietal, lateral occipital, and superior frontal regions as the main effects differentiating MCI‐DS from the CS groups. The largest annualized amyloid increases in longitudinal CS data were in the rostral middle frontal, superior frontal, superior/middle temporal, and posterior cingulate cortices. Discussion This study helps us to understand amyloid in the MCI‐DS transitional state between cognitively stable aging and frank dementia in DS. The spatial distribution of Aβ may be a reliable indicator of MCI‐DS in DS.