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Trajectories of pain and anxiety in a longitudinal cohort of adolescent twins
Author(s) -
Battaglia Marco,
GaronCarrier Gabrielle,
Brendgen Mara,
Feng Bei,
Dionne Ginette,
Vitaro Frank,
Tremblay Richard E.,
Boivin Michel
Publication year - 2020
Publication title -
depression and anxiety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.634
H-Index - 129
eISSN - 1520-6394
pISSN - 1091-4269
DOI - 10.1002/da.22992
Subject(s) - anxiety , medicine , odds ratio , longitudinal study , cohort , twin study , psychiatry , pediatrics , heritability , pathology , biology , genetics
Background Adolescence is critical to intercept chronic/persistent pain and decipher its association with anxiety. We ascertained adolescent pain trajectories, their demographic and clinical correlates, the longitudinal association with opiate prescriptions at age 19, and the etiology of the covariation between adolescent pain problems and anxiety symptoms. Methods Longitudinal assessment of: 6 common pain problems at age 12, 13, 14, 15, and 17 years; 7 common anxiety symptoms at age 12, 13, and 14 years; opiates’ prescriptions at age 19, in the Quebec Newborn Twin Study birth cohort of 667 twin pairs born between 1995–1998. Results Analyses yielded three trajectories of: “none‐to‐minimal” (34.3%), “sporadic” (56.7%), and “frequent” (9.0%) pain problems between age 12–17. Anxiety (odds ratios [OR] OR age12 : 2.38; confidence interval [CI]: 1.26–4.47; OR age13 : 3.96; CI: 1.73–9.05; OR age14 : 5.45; CI: 2.67–11.11), the female sex (OR: 3.69; CI: 2.20–6.21), and lower socioeconomic status (OR: 0.87; CI: 0.77–0.98) were associated with the “frequent” compared to the “none‐to‐minimal” pain trajectory. Only the “frequent” pain trajectory predicted opioid prescriptions at age 19 (OR: 4.14; CI: 1.16–14.55). A twin bivariate latent growth curve model and a cross‐lagged model showed that genetic factors and non‐shared environmental factors common to both phenotypes influence the longitudinal association between anxiety and adolescent pain problems. Conclusions The relatively common, adolescent “frequent pain” trajectory predicts early opioid prescriptions, and anxiety and adolescent pain share multiple etiological components. These data can inform diagnostic reasoning, clinical practice, and help reducing opioid prescriptions and abuse.