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The neural correlates of thought–action fusion in healthy adults: A functional magnetic resonance imaging study
Author(s) -
Lee Sang Won,
Cha Hyunsil,
Chung Younjae,
Kim Eunji,
Song Huijin,
Chang Yongmin,
Lee Seung Jae
Publication year - 2019
Publication title -
depression and anxiety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.634
H-Index - 129
eISSN - 1520-6394
pISSN - 1091-4269
DOI - 10.1002/da.22933
Subject(s) - precuneus , functional magnetic resonance imaging , anterior cingulate cortex , psychology , neuroscience , insula , prefrontal cortex , lingual gyrus , neural correlates of consciousness , superior frontal gyrus , brain mapping , cognition
Background Thought–action fusion (TAF) represents an individual's belief that a thought is like action. Inflated TAF has been considered a central mechanism for developing obsessive thoughts. However, the neural mechanisms underlying TAF are yet unknown. Methods We recruited 32 healthy men to participate in a functional magnetic resonance imaging (fMRI) study. Whereas inside the 3T MRI scanner, participants were asked to read negative statements describing the expectation of bad events associated with close persons (CPs condition) or neutral persons (NPs condition). They also completed the assessment of TAF and obsessive–compulsive (OC) symptoms. Results Both CP and NP conditions commonly activated the lingual gyrus, caudate nucleus, precuneus, and several areas of the frontal cortex. Importantly, many of these regions were positively correlated with measures of OC symptoms, especially for the CP condition. The CP condition showed higher activation in the insula and temporal gyrus than the NP condition. In contrast, the NP condition evoked higher activation in regions associated with mentalizing, such as the medial prefrontal cortex and dorsal anterior cingulate cortex than the CP condition. Conclusions We introduced and validated a TAF‐induction paradigm suitable for fMRI studies and characterized the neural circuits engaged during this paradigm. Further studies using this task may help us to better understand how dysfunctions in TAF neural processing may contribute to psychiatric conditions such as obsessive–compulsive disorder.