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Brain cytochrome‐c‐oxidase as a marker of mitochondrial function: A pilot study in major depression using NIRS
Author(s) -
Holper Lisa,
Lan Martin J,
Brown Patrick J,
Sublette Elizabeth M.,
Burke Ainsley,
Mann John J
Publication year - 2019
Publication title -
depression and anxiety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.634
H-Index - 129
eISSN - 1520-6394
pISSN - 1091-4269
DOI - 10.1002/da.22913
Subject(s) - bipolar disorder , major depressive disorder , medicine , cytochrome c oxidase , mood disorders , biomarker , depression (economics) , cerebral blood flow , prefrontal cortex , endocrinology , mood , cardiology , psychiatry , mitochondrion , lithium (medication) , biology , biochemistry , cognition , anxiety , macroeconomics , economics
Background Brain mitochondrial dysfunction is implicated in the pathophysiology of mood disorders. Brain cytochrome‐c‐oxidase (COX) activity is associated with the mitochondrial function. Near‐infrared spectroscopy (NIRS) noninvasively measures oxidized COX (oxCOX) and tissue oxygenation index (TOI) reflecting cerebral blood flow and oxygenation. Methods oxCOX and TOI were assessed in prefrontal cortex (Fp1/2, Brodmann area 10) in patients in a major depressive episode ( N = 13) with major depressive disorder (MDD; N = 7) and bipolar disorder (BD; N = 6) compared with the controls ( N = 10). One patient with MDD and all the patients with BD were taking medications. Computational modeling estimated oxCOX and TOI related indices of mitochondrial function and cerebral blood flow, respectively. Results oxCOX was lower in patients than controls ( p = .014) correlating inversely with depression severity ( r = −.72; p = .006), driven primarily by lower oxCOX in BD compared with the controls. Computationally modeled mitochondrial parameters of the electron transport chain, such as the nicotinamide adenine dinucleotide ratio (NAD + /NADH; p = .001) and the proton leak rate across the inner mitochondrial membrane (k lk2 ; p = .008), were also lower in patients and correlated inversely with depression severity. No such effects were found for TOI. Conclusions In this pilot study, oxCOX and related mitochondrial parameters assessed by NIRS indicate an abnormal cerebral metabolic state in mood disorders proportional to depression severity, potentially providing a biomarker of antidepressant effect. Because the effect was driven by the medicated BD group, findings need to be evaluated in a larger, medication‐free population.