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Familial aggregation of major depressive disorder in an African‐American community
Author(s) -
Murphy Eleanor,
Gangwisch James E.,
Matsunaga Janet T.,
Ottman Ruth
Publication year - 2018
Publication title -
depression and anxiety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.634
H-Index - 129
eISSN - 1520-6394
pISSN - 1091-4269
DOI - 10.1002/da.22775
Subject(s) - major depressive disorder , depression (economics) , confidence interval , odds ratio , poisson regression , relative risk , family history , logistic regression , family aggregation , medicine , psychiatry , psychology , clinical psychology , demography , disease , population , mood , economics , macroeconomics , environmental health , sociology
Background African Americans (AAs) with major depressive disorder (MDD) experience more impairment and poorer treatment outcomes relative to Whites, yet are underrepresented in family studies of MDD. This is the first study to investigate the familial aggregation of major depression among AAs. Methods Participants' reports of depression from clinical and family history (FH) interviews were used to examine depression rates among 435 first‐degree relatives and half‐siblings of 63 depressed cases and 222 relatives of 33 nondepressed controls. Binary logistic regression was used to compute odds ratios (ORs) for FH of MDD and level of trauma exposure (high and low) in cases versus controls. Poisson regression models with generalized estimating equations were used to assess MDD in relatives of cases versus relatives of controls. Results Cases and controls did not differ in either FH of MDD (OR = 1.2, 95% confidence interval [CI] = 0.5–2.9), or prevalence of MDD in relatives (relative risk [RR] = 1.5, 95% CI = 0.8–2.5). However, exposure to high trauma was associated with increased risk of MDD (OR = 3.0, 95% CI = 1.22–7.17) and the combined effect of FH and trauma was greater than expected under an additive model. Similarly, the RR for MDD among relatives of cases with high‐trauma levels was 2.2 (1.24–4.2), compared to relatives of controls with low trauma. Conclusion The effect of FH of MDD appears to be exacerbated among individuals exposed to high trauma. Replication and further research on the chronology and subtypes of trauma and MDD, and their interactions, remain essential in AA populations.