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TYPE 2 DIABETES IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER: A META‐ANALYSIS OF PREVALENCE ESTIMATES AND PREDICTORS
Author(s) -
Vancampfort Davy,
Mitchell Alex J.,
Hert Marc,
Sienaert Pascal,
Probst Michel,
Buys Roselien,
Stubbs Brendon
Publication year - 2015
Publication title -
depression and anxiety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.634
H-Index - 129
eISSN - 1520-6394
pISSN - 1091-4269
DOI - 10.1002/da.22387
Subject(s) - major depressive disorder , meta analysis , medicine , confidence interval , depression (economics) , type 2 diabetes , relative risk , type 2 diabetes mellitus , population , epidemiology , observational study , diabetes mellitus , psychiatry , demography , endocrinology , environmental health , amygdala , economics , macroeconomics , sociology
Background Patients with depression may be at increased risk of type 2 diabetes mellitus (T2DM), which is a risk factor for cardiovascular diseases and premature mortality. We aimed to clarify the prevalence and predictors of T2DM in patients with major depressive disorder (MDD) and where possible compare the prevalence of T2DM in those with MDD versus general population controls. Methods We searched major electronic databases until December 2014 for studies reporting T2DM prevalence in patients with MDD. Two independent authors extracted data and completed methodological quality appraisal in accordance with the meta‐analysis of observational studies in epidemiology (MOOSE) guidelines. A random effects meta‐analysis was utilized. Results The initial electronic database search resulted in 145 valid hits and 16 publications with clearly defined MDD ( n = 15,8834; 31% male; mean age = 39–78 years) met the eligibility criteria. The overall prevalence of T2DM was 8.7% (95% confidence interval [CI] = 7.3–10.2%). Mean age of the MDD sample predicted a higher prevalence of T2DM (β = 0.0411; 95% CI = 0.0032–0.079, P = .03; R ² = .22). A comparative meta‐analysis revealed people with MDD ( n = 154,366) had a higher risk of T2DM versus general controls ( n = 2,098,063; relative risk [RR] = 1.49; 95% CI = 1.29–1.72; P < 0.001, N = 10). The RR ( N = 3) focusing on age‐ and gender‐matched general population controls ( n = 103,555) was 1.36 (95% CI = 1.28–1.44; P < 0.001, n [MDD] = 10,895). Conclusions T2DM is significantly more common in people with MDD compared with the general population. The current meta‐analysis indicates that action is needed in order to curb the diabetes epidemic in this high‐risk population.