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POTENTIATED PROCESSING OF NEGATIVE FEEDBACK IN DEPRESSION IS ATTENUATED BY ANHEDONIA
Author(s) -
Mueller Erik M.,
Pechtel Pia,
Cohen Andrew L.,
Douglas Samuel R.,
Pizzagalli Diego A.
Publication year - 2015
Publication title -
depression and anxiety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.634
H-Index - 129
eISSN - 1520-6394
pISSN - 1091-4269
DOI - 10.1002/da.22338
Subject(s) - anhedonia , depression (economics) , psychology , neuroscience , clinical psychology , medicine , psychiatry , keynesian economics , schizophrenia (object oriented programming) , economics
Background Although cognitive theories of depression have postulated enhanced processing of negatively valenced information, previous EEG studies have shown both increased and reduced sensitivity for negative performance feedback in MDD. To reconcile these paradoxical findings, it has been speculated that sensitivity for negative feedback is potentiated in moderate MDD, but reduced in highly anhedonic subjects. The goal of this study was to test this hypothesis by analyzing the feedback‐related negativity (FRN), frontomedial theta power (FMT), and source‐localized anterior midcingulate cortex (aMCC) activity after negative feedback. Methods Fourteen unmedicated participants with Major Depressive Disorder (MDD) and 15 control participants performed a reinforcement learning task while 128‐channel Electroencephalogram (EEG) was recorded. FRN, FMT, and LORETA source‐localized aMCC activity after negative and positive feedback were compared between groups. Results The MDD group showed higher FRN amplitudes and aMCC activation to negative feedback than controls. Moreover, aMCC activation to negative feedback was inversely related to self‐reported anhedonia. In contrast, self‐reported anxiety correlated with feedback‐evoked frontomedial theta (FMT) within the depression group. Conclusions The present findings suggest that, among depressed and anxious individuals, enhanced processing of negative feedback occurs relatively early in the information processing stream. These results extend prior work and indicate that although moderate depression is associated with elevated sensitivity for negative feedback, high levels of anhedonia may attenuate this effect.