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EFFECTS OF ARIPIPRAZOLE AUGMENTATION IN TREATMENT‐RESISTANT OBSESSIVE‐COMPULSIVE DISORDER (A DOUBLE BLIND CLINICAL TRIAL)
Author(s) -
Sayyah Mehdi,
Sayyah Mohammad,
Boostani Hatam,
Ghaffari Seyyed Mohammad,
Hoseini Abedin
Publication year - 2012
Publication title -
depression and anxiety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.634
H-Index - 129
eISSN - 1520-6394
pISSN - 1091-4269
DOI - 10.1002/da.21996
Subject(s) - aripiprazole , placebo , obsessive compulsive , medicine , psychiatry , double blind , antipsychotic , randomized controlled trial , clinical trial , psychology , schizophrenia (object oriented programming) , alternative medicine , pathology
Background Obsessive‐compulsive disorder ( OCD ) is a chronic disorder with unknown etiology. Failure in OCD treatmentcompulsive is common and finding effective augmentations in treatment of OCD will benefit patients. Antipsychotic augmentation is a common strategy for treatment resistant OCD . This trial evaluated the efficacy of adding aripiprazole in patients whose OCD was insufficiently responsive to an adequate SSRI treatment. Methods Thirty‐nine adult outpatients, who met the DSM ‐IV‐ TR criteria for OCD and had treatment resistant OCD were evaluated in a double‐blind randomized clinical trial. The patients received either aripiprazole 10 mg/day or placebo, for 12 weeks. Data were analyzed using intention‐to‐treat analysis with last observation carried forward. All statistical tests were two‐sided, and were considered statistically significant at P < 0.05. Results A significant reduction in total scores of Y ‐ BOCS ( P < 0.0001) was found in the aripiprazole group. Aripiprazole was generally well tolerated. There was no significant difference between the two groups in terms of observed side effects. Conclusion Results of the present study indicate that aripiprazole could be an effective augmentation medicine in treatment resistant OCD .