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BRAIN ACTIVATION TO FACIAL EXPRESSIONS IN YOUTH WITH PTSD SYMPTOMS
Author(s) -
Garrett Amy S.,
Carrion Victor,
Kletter Hilit,
Karchemskiy Asya,
Weems Carl F.,
Reiss Allan
Publication year - 2012
Publication title -
depression and anxiety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.634
H-Index - 129
eISSN - 1520-6394
pISSN - 1091-4269
DOI - 10.1002/da.21892
Subject(s) - amygdala , functional magnetic resonance imaging , ventrolateral prefrontal cortex , psychology , prefrontal cortex , facial expression , insula , dorsolateral prefrontal cortex , hippocampus , voxel , audiology , neuroscience , clinical psychology , medicine , cognition , communication , radiology
Objective This study examined activation to facial expressions in youth with a history of interpersonal trauma and current posttraumatic stress symptoms ( PTSS ) compared to healthy controls ( HC ). Design and analysis Twenty‐three medication‐naive youth with PTSS and 23 age‐ and gender‐matched HC underwent functional magnetic resonance imaging (f MRI ) while viewing fearful, angry, sad, happy, and neutral faces. Data were analyzed for group differences in location of activation, as well as timing of activation during the early versus late phase of the block. Using SPM 5, significant activation (P < .05 FWE [Family‐Wise Error] corrected, extent = 10 voxels) associated with the main effect of group was identified. Activation from selected clusters was extracted to SPSS software for further analysis of specific facial expressions and temporal patterns of activation. Results The PTSS group showed significantly greater activation than controls in several regions, including the amygdala/hippocampus, medial prefrontal cortex, insula, and ventrolateral prefrontal cortex, and less activation than controls in the dorsolateral prefrontal cortex ( DLPFC ). These group differences in activation were greatest during angry, happy, and neutral faces, and predominantly during the early phase of the block. Post hoc analyses showed significant Group × Phase interactions in the right amygdala and left hippocampus. Conclusions Traumatic stress may impact development of brain regions important for emotion processing. Timing of activation may be altered in youth with PTSS .