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Protein synthesis inhibition before or after stress exposure results in divergent endocrine and BDNF responses disassociated from behavioral responses
Author(s) -
Kozlovsky Nitsan,
Kaplan Zeev,
Zohar Joseph,
Matar Michael A.,
Shimon Hady,
Cohen Hagit
Publication year - 2008
Publication title -
depression and anxiety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.634
H-Index - 129
eISSN - 1520-6394
pISSN - 1091-4269
DOI - 10.1002/da.20366
Subject(s) - anisomycin , tropomyosin receptor kinase b , psychology , startle response , medicine , neurotrophic factors , corticosterone , anxiety , endocrinology , synaptic plasticity , brain derived neurotrophic factor , startle reaction , elevated plus maze , neuroscience , hormone , protein biosynthesis , biology , psychiatry , receptor , reflex , microbiology and biotechnology
This study aimed to assess the effects of anisomycin, a protein synthesis inhibitor, on behavioral responses, brain‐derived neurotrophic factor (BDNF) and TrkB mRNA levels, and circulating corticosterone in rats—when administered before or after initial exposure to a predator scent stress stimulus. Magnitude of changes in prevalence of anxiety‐like behaviors on the elevated plus‐maze and exaggerated startle reaction as well as corticosterone levels and mRNA BDNF and TrkB were compared in rats exposed to predator stress, microinjected with anisomycin before or after stress exposure. Administration of anisomycin before or after stress exposure reduced anxiety‐like behavior in the elevated plus‐maze and reduced the mean startle amplitude 7 days postexposure. Although the behavioral responses were similar when anisomycin was microinjected before or after stress exposure, the levels of mRNAs for BDNF and TrkB, which play a role in modulation of synaptic plasticity and the consolidation process, showed varying responses. Depression and Anxiety 0:1–11, 2007. © 2007 Wiley‐Liss, Inc.